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Reviewed by John Caruso, FSA, MAAA • Data last updated

Chemotherapy Infusion Cost in Illinois (2026): Average Prices & What You'll Pay

What does a chemotherapy infusion cost in Illinois?

You could pay $351 or $693 for the same chemotherapy infusion in Illinois - depending entirely on which facility you choose. The median cash price across 116 reporting hospitals is $377. This data comes directly from hospital price transparency files published under federal law. The sections below break this down by coverage and by insurer.

Three low-priced facilities in Illinois, from hospital price files

  • St. Alexius Medical Center $150
  • Alexian Brothers Medical Center $150
  • McDonough County Hospital District $150

All 116 facilities are listed below, free.

Where chemotherapy infusion costs vary in Illinois

Pins show hospitals with price-transparency data (colored by vs. state average) and nearby outpatient clinics and other facilities (colored by type). Click any pin for facility name and estimated cost range.

Hospital (below avg) Hospital (above avg) Click a pin for details.

26+ people checked prices near them this month.

What you pay for a chemotherapy infusion depends on where you go and what is billed separately. Most patients find out after.

Your personalized cost report includes:

  • ✓ The drugs are not included: Chemotherapy drugs are billed on their own and are usually most of the bill.
  • ✓ Time: The first hour is priced here, and each additional hour is an add-on.
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  • ✓ The questions to ask before you schedule, so the estimate covers everything
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Cheapest Chemotherapy Infusion Providers in Illinois

Based on declared cash/self-pay prices from CMS hospital price transparency files.

# Facility City Price vs median ($377)
1 St. Alexius Medical Center IL $150 $227 below
2 Alexian Brothers Medical Center IL $150 $227 below
3 McDonough County Hospital District IL $150 $227 below
4 MercyOne Genesis Silvis Medical Center Silvis, IL $166 $211 below
5 Resilience Healthcare West Suburban Medical Center LLC Oak Park, IL $190 $187 below
6 Hardin County General Hospital Rosiclare, IL $190 $187 below
7 Deaconess Illinois Union County Hospital Inc Anna, IL $198 $179 below
8 OSF Healthcare System Evergreen Park, IL $206 $171 below

Prices are declared self-pay rates. Contact each facility for a formal quote before scheduling.

Before you book: three questions that change the price

  1. Is this the self-pay price, and does it include the doctor, anesthesia and any lab or pathology? Those are often billed separately.
  2. Can you give me the price in writing, with the billing codes it covers?
  3. What happens to the price if something extra is needed during the procedure?

Estimate your out-of-pocket cost →  ·  When the bills arrive, we check them for errors →

Quick take

  • St. Alexius Medical Center is the lowest-cost option at $150 - $227 below the median posted price ($377), just by choosing where you go.
  • Ask for the cash price if your deductible isn't met - the median cash price here is $378, and it's often lower than what insurance pays before your deductible is satisfied.
  • Doctor offices and independent clinics may charge differently from hospitals for the same service and may not appear in this hospital-only dataset. Ask your doctor whether another site is an option.
Chemotherapy infusion prices by coverage in Illinois, October 2026
CoverageHospitals with a rateTypical rangeMedian
Medicare (national rate)—$337 to $337$337
With insurance (commercial, average)78$302 to $828$494
Without insurance (cash price)114$150 to $1,005$378
Blue Cross and Blue Shield of Illinois69$176 to $857$363
Aetna59$326 to $896$490
UnitedHealthcare53$205 to $928$531
Cigna46$330 to $925$566

Rates are negotiated allowed amounts and cash prices from hospital price-transparency files (October 2026), shown at each hospital’s lowest-priced typical billing code for this procedure. Facility fees only. The typical range is the middle 80% of hospitals, not a quote for your visit.

How much does a chemotherapy infusion cost with Medicare in Illinois?

Medicare's national hospital outpatient payment for chemotherapy infusion is about $337 to $337 (typically near $337). After the $257 Part B deductible, you generally pay 20% of the Medicare-approved amount, about $67 on a $337 payment, with no out-of-pocket cap unless you have supplemental coverage or a Medicare Advantage plan.

Doctor, anesthesia and pathology fees are billed separately. Medicare rates are national CMS amounts, adjusted slightly by local wage levels.

How much does a chemotherapy infusion cost with insurance in Illinois?

Across 78 Illinois hospitals, the negotiated rates commercial insurers pay for chemotherapy infusion average $302 to $828 per hospital, with a median near $494. That is the amount your plan and you pay the hospital together; you owe your deductible, then coinsurance, up to your out-of-pocket maximum.

Each hospital’s figure is the average of the commercial insurers it lists. Medicare, Medicare Advantage and Medicaid rates are excluded.

How much does a chemotherapy infusion cost without insurance in Illinois?

Cash (self-pay) prices for chemotherapy infusion at 114 Illinois hospitals range from $150 to $1,005, with a median of $378. Ask for the cash or self-pay price and for any financial-assistance discount before you book; both can be lower than the posted price.

Cash prices are the hospital’s published discounted rate for patients paying without insurance.

How much does a chemotherapy infusion cost with Blue Cross and Blue Shield of Illinois?

Blue Cross and Blue Shield of Illinois negotiated rates for chemotherapy infusion at 69 Illinois hospitals range from $176 to $857, with a median near $363. Your own cost depends on your plan’s deductible and coinsurance, and on whether the hospital is in your network.

Includes Blue Cross and Blue Shield and Anthem plans listed by each hospital.

How much does a chemotherapy infusion cost with Aetna in Illinois?

Aetna negotiated rates for chemotherapy infusion at 59 Illinois hospitals range from $326 to $896, with a median near $490. If a hospital is out of network for your Aetna plan, you may owe more than the negotiated rate, so check the network first.

How much does a chemotherapy infusion cost with UnitedHealthcare in Illinois?

UnitedHealthcare negotiated rates for chemotherapy infusion at 53 Illinois hospitals range from $205 to $928, with a median near $531. If a hospital is out of network for your UnitedHealthcare plan, you may owe more than the negotiated rate, so check the network first.

How much does a chemotherapy infusion cost with Cigna in Illinois?

Cigna negotiated rates for chemotherapy infusion at 46 Illinois hospitals range from $330 to $925, with a median near $566. If a hospital is out of network for your Cigna plan, you may owe more than the negotiated rate, so check the network first.

How where you go changes what you pay for chemotherapy infusion

The same chemotherapy infusion bundles different services depending on the setting - facility fee, surgeon fee, and anesthesia each arrive as separate bills. Estimated ranges below reflect the typical full bundled cost, including all expected charges.

Hospital Outpatient
$202–$5,254
  • Facility fee $17–$4,762
  • Professional fee $185–$492

Estimated from CMS fee schedules + commercial rate multipliers

Hospital Inpatient
$309–$1,460
  • Facility fee $124–$968
  • Professional fee $185–$492

Estimated from CMS fee schedules + commercial rate multipliers

Illinois presents two distinct markets: Chicago (highly competitive, high commercial rates, major academic medical centers) and downstate (lower density, smaller regional systems, lower rates). Northwestern Medicine, Advocate Aurora Health, and Rush University Medical Center compete aggressively in the Chicago market. Downstate Illinois prices typically run 20–35% below Chicago-area rates for identical services.

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Why prices vary - and what it means for your coverage

A small number of hospitals (2) report prices above $1,358, including Shriners Childrens - Chicago at $1,643, which drives most of the overall spread - excluding them, most facilities cluster in a much tighter band. Setting matters too: the median outpatient price is $377 versus $622 inpatient (about 1.6× more), so where a procedure happens often matters more than which hospital you pick.

None of the prices above are what you'll necessarily owe: your deductible, out-of-pocket maximum, and each provider's network status all still apply.

Your situation Estimated out-of-pocket
Deductible not yet met ~$377
Deductible met - 20% coinsurance ~$75
Out-of-network provider $829+

Frequently asked questions: chemotherapy infusion costs in Illinois

How much does a chemotherapy infusion cost in Illinois?

The typical insurer-negotiated rate is $178, with most facilities between $129 and $241 (based on 111 hospitals reporting negotiated rates). Posted cash prices at the middle 80% of Illinois hospitals run $150–$1,005; outlier facilities above and below that range are left out. What you pay depends on the facility, your insurance, and whether you have met your deductible.

Where is the cheapest place to get a chemotherapy infusion in Illinois?

Based on declared prices, the lowest posted price in our Illinois data is St. Alexius Medical Center at about $150. By metro, Rockford has the lowest median ($248).

Why is a chemotherapy infusion so much cheaper at some Illinois hospitals?

Typical prices vary about 1.9× (25th to 70th percentile of negotiated rates) because each hospital sets its own list price, cash discount, and insurer-negotiated rates. In Illinois, the median cash (self-pay) price is $378 versus a median negotiated rate of $494 - cash is the lower number at many hospitals. Asking for the cash price as well as your insurer's negotiated rate is often the single biggest lever on what you pay.

How much will I actually pay out of pocket for a chemotherapy infusion in Illinois?

Your out-of-pocket cost depends on your deductible, coinsurance, out-of-pocket maximum, and whether the facility is in-network - not just the sticker price. If you have not met your deductible, you will typically pay the negotiated rate in full until you do. Use the CostKits cost forecaster to estimate your specific out-of-pocket amount before you go.

Before you book

Other procedures in Illinois

Chemotherapy Infusion, elsewhere

CostKits compiles hospital price transparency data to help families make informed decisions. Track and manage your healthcare costs (free account).

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About the Author

John Caruso, FSA, MAAA

Healthcare actuary with 20+ years of experience in insurance pricing, medical billing systems, and healthcare cost analytics.

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Published October 29, 2026 · Updated October 29, 2026

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